![]() Ishibazawa A, Nagaoka T, Takahashi A et al (2015) Optical coherence tomography angiography in diabetic retinopathy: a prospective pilot study. Khadamy J, Abri Aghdam K, Falavarjani KG (2018) An update on optical coherence tomography angiography in diabetic retinopathy. JAMA Ophthalmol 133:45–50ĪttaAllah HR, Mohamed AAM, Ali MA (2019) Macular vessels density in diabetic retinopathy: quantitative assessment using optical coherence tomography angiography. Spaide RF, Klancnik JM Jr, Cooney MJ (2015) Retinal vascular layers imaged by fluorescein angiography and optical coherence tomography angiography. Hagag AM, Gao SS, Jia Y, Huang D (2017) Optical coherence tomography angiography: technical principles and clinical applications in ophthalmology. PLoS ONE 12:e0177059ĭeBuc DC (2016) The role of retinal imaging and portable screening devices in tele-ophthalmology applications for diabetic retinopathy management. ![]() Munk MR, Giannakaki-Zimmermann H, Berger L, Huf W, Ebneter A, Wolf S, Zinkernagel MS (2017) OCT-angiography: a qualitative and quantitative comparison of 4 OCT-A devices. Garrity ST, Iafe NA, Phasukkijwatana N, Chen X, Sarraf D (2017) Quantitative analysis of three distinct retinal capillary plexuses in healthy eyes using optical coherence tomography angiography. Stanga PE, Tsamis E, Papayannis A, Stringa F, Cole T, Jalil A (2016) Swept-source optical coherence tomography Angio TM (Topcon Corp, Japan): technology review. ĭe Barros Garcia JMB, Isaac DLC, Avila M (2017) Diabetic retinopathy and OCT angiography: clinical findings and future perspectives. Ophthalmology 127:P66–P145Īmerican Diabetes Association (2020) Standards of medical care in diabetes-2020. Ann Intern Med 116:660–671įlaxel CJ, Adelman RA, Bailey ST et al (2020) Diabetic retinopathy preferred practice pattern®. Singer DE, Nathan DM, Fogel HA et al (1992) Screening for diabetic retinopathy. Witkin SR, Klein R (1984) Ophthalmologic care for persons with diabetes. Wang W, Lo ACY (2018) Diabetic retinopathy: pathophysiology and treatments. Conclusionĭiabetic patients without DR demonstrate early microvascular alteration in the macular area on OCT-A, which is more pronounced in type I DM, and correlates with the duration of the disease. Statistically significant differences in the FAZ area at SCP and DCP were observed when comparing patients with a diabetes duration > 10 years and < 10 years in the DM2 group ( p = .0001, respectively) and only in the FAZ area at the DCP in the DM1 group ( p = .0001). A direct correlation was found between the duration of diabetes and SCP FAZ area ( r = 0.44 R 2 = 0.19 p = .0001). The VD was significantly reduced in DM1 and DM2 groups compared to controls. Additionally, no significant differences in FAZ area were found between the DM1 and DM2 groups ( p = .26). The SCP and DCP FAZ areas were significantly larger in the DM1 group in comparison with the controls ( p = .001), while no significant differences were observed between the DM2 group and the healthy control group ( p = .12). The foveal avascular zone (FAZ) area and the vessel density (VD) at the superficial capillary plexus (SCP) and deep capillary plexus (DCP) were evaluated. This prospective study involved 93 patients with type 1 diabetes (DM1), 104 patients with type 2 diabetes (DM2) without signs of DR, and 71 healthy subjects for the control group. To analyze the early macular microvascular alterations in patients with type 1 and 2 diabetes mellitus (DM) without diabetic retinopathy (DR), using optical coherence tomography angiography (OCT-A), and compare these with nondiabetic patients.
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